Working with the Asia Cohort Consortium
The ACC encourages the collaboration of researchers with similar interests. The primary activities of the ACC consist of advancing the development of new cohorts and pursuing cross-cohort collaborative projects. Cohort development within the ACC has begun in Korea, Singapore and Malaysia through the establishment of newly funded cohorts in those countries. The ACC is committed to supporting these cohorts and assisting the development of similar cohorts throughout the region. Researchers interested in developing a new cohort are encouraged to contact the ACC Coordinating Center (CC) at cc@asiacohort.org for further information.
The ACC is also committed to pursuing cross-cohort collaborative projects which require large-scale efforts. The ACC is currently involved in a collaborative project investigating body mass index (BMI) and cause-specific mortality among nearly twenty cohorts throughout Asia. Consortium members are also in the early stages of developing additional projects which will focus on 1) cancer of the small intestine, a rare cancer, difficult to study without very large populations; and 2) a pilot study to demonstrate ways in which biospecimens can be used across existing Asian cohorts. Both of these projects are expected to begin in 2009. The ACC will consider additional project proposals in the areas of:
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diet & nutrition
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obesity & physical activity
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occupation & environment
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medical & reproductive history
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alcohol & tobacco use
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family history & genetics
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biospecimens & sample collection
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data collection & management
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follow-up & endpoint ascertainment
Researchers interested in proposing collaborative projects are encouraged to read the following sections and contact the CC at cc@asiacohort.org for further information.
Proposals
An investigator who is interested in initiating a collaborative project will need to submit a proposal and project submission cover sheet to the ACC Coordinating Center. The project submission cover sheet can be found here
. Both the proposal and cover sheet should be submitted electronically to the CC at cc@asiacohort.org. Proposals will be accepted from any individual interested in collaborating with the ACC, including non-ACC members. Proposals originating outside of the ACC must first secure a sponsoring ACC member. The CC can assist in arranging an ACC sponsor if needed.
Proposals should be a concise summary of the proposed project, and include the following areas: Rationale and Significance, Specific Aims, Study Design, and Research Methods. The proposal should also address the specific issues of project oversight, decision-making, the role of the CC, data-sharing arrangements, authorship and project milestones. While proposals should be as close to the implemented project as possible, it is understood that in the initial stages, proposals are working documents which are subject to change during the review process. The CC can provide a sample proposal upon request and can also assist in the development of the proposal if necessary.
Proposals will be accepted continuously throughout the year and will be sent to the Executive Committee (EC) for initial review. Proposals which support the ACC mission and are deemed scientifically sound will be slated for review at the next scheduled bi-annual Steering Committee (SC) meeting. Proposals will then be posted on the ACC secure members portal to allow SC members to review proposals in advance of the meeting. As the review process is intended to be a discussion which advances collaboration, project participants and SC members are encouraged to discuss project design and logistics on portal discussion boards following posting. If an expedited review is necessary and feasible, the review will be done entirely online. This expedited review should be requested by the proposal’s investigator.
Though not required, proposal authors will have the opportunity to present proposals at an ACC bi-annual Steering Committee (SC) meeting. The SC may also request a brief presentation of a proposal to assist the committee’s review. This presentation will allow project proponents and SC members to exchange thoughts and further project development.
While there are no formal evaluation criteria, the SC will pay particular attention to the project’s relevance to the ACC mission, merit of a large-scale collaborative effort, degree of scientific quality, and potential contribution to the area of study. Bi-annual meetings will allot time for the SC to discuss these issues and communicate with project proponents, if in attendance.
SC members will then vote on reviewed proposals. For a proposal to be accepted, it must be approved by a majority of the SC members present, assuming that there is a quorum. In some instances, the SC may recommend changes to a proposal prior to acceptance. In such cases, the SC will communicate with the proposal’s lead author to discuss where alterations are possible. It is hoped that this will further the project’s design and continue to build a collaborative environment among individuals committed to the project’s success.
If applicable, proposals will also be reviewed by an appropriate working group at some point in the review process. For example, all proposals involving biospecimens will receive review by the Biospecimens Working Group. Working groups will not have authority to approve proposals, but are responsible for advising the SC and proposal authors on protocol, policy, and procedural issues pertaining to their respective areas of expertise.
Post-Approval
Upon acceptance, the CC will assist project proponents in the formation of or assignment to a working group (WG) and development of communication structures for the WG. During the course of the project, working groups are responsible, with the help of the CC, for the advancement of the project as outlined. The CC is available to assist WGs with logistical needs of the project such as Fred Hutchinson Center IRB compliance, document preparation, and data analysis.
Please contact the CC at cc@asiacohort.org for any questions regarding the process for collaborative projects within the ACC.