The Asia Cohort Consortium

Publication Highlights

ACC recent publication highlight 2023-2024

*for more ACC publications, please see  Publications 

Diabetes and gastric cancer incidence and mortality in the Asia Cohort Consortium: A pooled analysis of more than a half million participants

J Diabetes. 2024; 16(6):e13561, Published: May 16, 2024 
Evidence suggests a possible link between diabetes and gastric cancer risk, but the findings remain inconclusive, with limited studies in the Asian population. This study assessed the impact of diabetes and diabetes duration on the development of gastric cancer overall, by anatomical and histological subtypes using pooled data from 12 studies from the Asia Cohort Consortium.

Diabetes was associated with an increased gastric cancer incidence regardless of sex, anatomical subsite, or histological subtypes of gastric cancer. The risk of gastric cancer was particularly high during the first decade following diabetes diagnosis.

Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants

 Gastric Cancer. published online April 2024
The family history of gastric cancer holds important implications for cancer surveillance and prevention, yet existing evidence predominantly comes from case-control studies. This study included 12 prospective cohorts with more than half a million participants in the Asia Cohort Consortium to investigate the association between family history of gastric cancer and gastric cancer risk overall and by various subtypes in Asians. The findings indicate that a familial background of gastric cancer increases the risk of gastric cancer by approximately 50%, regardless of sex, anatomical subsite, or histological subtype in the Asian population.

Differential patterns of reproductive and lifestyle risk factors for breast cancer according to birth cohorts among women in China, Japan and Korea

 Breast Cancer Reserch. 2024;26(1):15, Published: January 22, 2024
The birth cohort effect has been suggested to influence the rate of breast cancer incidence and the trends of associated reproductive and lifestyle factors. This study was conducted to determine whether a differential pattern of associations exists between certain factors and breast cancer risk based on birth cohorts using pooled data from 12 cohort studies from the Asian Cohort Consortium.

We observed differential patterns of parity, smoking and alcohol consumption across birth cohorts. Reproductive risk factors were more apparent in the older birth cohorts, whereas smoking and alcohol use were only notable in the younger generation. 

Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortium

 International Journal of Cancer.  available online: November 16, 2023
While obesity is a probable risk factor for biliary tract cancer, the association is mediated by gallstones. To thoroughly comprehend the impact of BMI on biliary tract cancer risk, accounting for the effect of gallstones, we conducted a pooled analysis of 905,530 individuals from 21 cohort studies within the Asia Cohort Consortium. This study identified an association between higher BMI and increased mortality from biliary tract cancer. Notably, obesity elevates the risk of biliary tract cancer both directly and indirectly through gallstones, with this effect being evident in females.

Reproductive Factors and Endometrial Cancer Risk Among Women

 JAMA Netw Open. 2023;6(9):e2332296, Published: September 05, 2023
To assess the association between reproductive factors, such as number of deliveries, age at menarche, or menopause, and endometrial cancer risk in East Asia.
In this pooled cohort study of 332 625 women including 1005 endometrial cancer cases from 13 Asian cohort studies, late menarche, early menopause, and a greater number of deliveries were associated with a lower risk of endometrial cancer.
 The findings from this large pooled analysis in Asia, which are consistent with previous evidence, may have an impact on the understanding of risk factors for endometrial cancer.

Lung Cancer Risk Prediction Models for Asian Ever-Smokers

Journal of Thoracic Oncology.  available online: November 07, 2023 

  • While low-dose computed tomography (LDCT) screening has been increasingly implemented in many Asian countries, little is known about the performance of lung cancer risk prediction models that can be utilized to determine screening eligibility for Asians.
  • In a pooled analysis of 186,458 Asian ever-smokers from 19 prospective cohorts, we 1) assessed calibration (expected to observed ratios) and discrimination (area under the receiver operating characteristic curves) for 11 existing risk prediction models and 2) developed the ‘Shanghai models’ to better refine risk models for Asians.
  • Among 11 risk models, the PLCOm2012, LCRAT, and LCDRAT performed relatively better than other models overall, but poorly in predicting lung cancer risk among Asians who reported low-intensity smoking or who had quit smoking for prolonged periods.
  • The Shanghai models performed comparably to the best Western models in general, but their ability to predict the risk of low-intensity smokers and long-term quitters in Asia was significantly enhanced.
  • Our findings indicate the importance of incorporating Asia-specific risk estimates into personalized lung cancer risk assessment to better implement risk-based LDCT screening in Asia.